OphthFormPreclinic_HRZZ 04.01/56 Partner
Development of in vitro/ex vivo models for the permeability testing of new topical ophthalmic formulations
Cell-based models
With epithelial barrier properties that correlate well with those of an tissue-based model by analyzing the bioelectrical properties of the barrier formed.
With permeation rates that correlate well with those of tissue-based models by analyzing the apparent permeation coefficients of model compounds with varying degrees of lipophilicity, molecular sizes and charges.
Complex cell-based model
For ocular drug permeability testing, suitable for primary screening experi-ments in terms of cultivation time, reproducibility and standardization.
Tissue-based models
For ocular drug permeability testing suitable for large-scale secondary screening experiments.
Project Leader
Prof. Jelena Filipović-Grčić, PhD
She has in-depth experience in the development of polymeric micro- and/or nanoparticles for nasal, ocular and (trans)dermal delivery, as well as in drug release modeling. Recently, the focus of interest of her group in the emerging field of nanomedicine has been the development of nanodelivery systems for drug and gene therapy of ocular diseases, which requires the use of appropriate in vitro and/or ex vivo models of the ocular barrier, so that the optimization of these models is an integral part of the current research project.